Clathrin-mediated Endocytosis of Alpha-1 Antitrypsin is Essential for its Protective Function in Islet Cell Survival

Cytokine-induced pancreatic β cell death plays a pivotal role in both type 1 and type 2 diabetes. Our previous study showed that alpha-1 antitrypsin (AAT) inhibits β cell death through the suppression of cytokine-induced c-Jun N-terminal kinase (JNK) activation in an islet transplantation model. The...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Theranostics
Main Authors: Wang, Jingjing, Gou, Wenyu, Kim, Do-sung, Strange, Charlie, Wang, Hongjun
Format: Artigo
Jezik:Inglês
Izdano: Ivyspring International Publisher 2019
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6587339/
https://ncbi.nlm.nih.gov/pubmed/31281523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.31647
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