Alpha-1 antitrypsin suppresses macrophage activation and promotes islet graft survival after intrahepatic islet transplantation

Alpha-1 antitrypsin (AAT) has protective functions in animal islet transplantation models. While the therapeutic effect of AAT therapy is currently being tested in clinical trials, we investigated the mechanism of AAT protection in a clinically relevant marginal intrahepatic human islet transplantat...

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Bibliographic Details
Published in:Am J Transplant
Main Authors: Gou, Wenyu, Wang, Jingjing, Song, Lili, Kim, Do-Sung, Cui, Wanxing, Strange, Charlie, Wang, Hongjun
Format: Artigo
Language:Inglês
Published: 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8082666/
https://ncbi.nlm.nih.gov/pubmed/33047509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/ajt.16342
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