α-1 Antitrypsin Enhances Islet Engraftment by Suppression of Instant Blood-Mediated Inflammatory Reaction

Islet cell transplantation has limited effectiveness because of an instant blood-mediated inflammatory reaction (IBMIR) that occurs immediately after cell infusion and leads to dramatic β-cell death. In intraportal islet transplantation models using mouse and human islets, we demonstrated that α-1 a...

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Detalhes bibliográficos
Publicado no:Diabetes
Main Authors: Wang, Jingjing, Sun, Zhen, Gou, Wenyu, Adams, David B., Cui, Wanxing, Morgan, Katherine A., Strange, Charlie, Wang, Hongjun
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2017
Assuntos:
Immunology and Transplantation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5360304/
https://ncbi.nlm.nih.gov/pubmed/28069642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db16-1036
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