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The Molecular Basis of Drug Addiction: Linking Epigenetic to Synaptic and Circuit Mechanisms

Addiction is a disease in which, after a period of recreational use, a subset of individuals develops compulsive use that does not stop even in light of major negative consequences. Here, we review the evidence for underlying epigenetic remodeling in brain in two settings. First, excessive dopamine...

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Pubblicato in:Neuron
Autori principali: Nestler, Eric J., Lüscher, Christian
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6587180/
https://ncbi.nlm.nih.gov/pubmed/30946825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2019.01.016
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