The levels of the NMDA receptor co-agonist D-serine are reduced in the substantia nigra of MPTP-lesioned macaques and in the cerebrospinal fluid of Parkinson’s disease patients

Dysfunction of NMDA receptor (NMDAR)-mediated transmission is supposed to contribute to the motor and non-motor symptoms of Parkinson’s Disease (PD), and to L-DOPA-induced dyskinesia. Besides the main agonist L-glutamate, two other amino acids in the atypical D-configuration, D-serine and D-aspartat...

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Опубликовано в: :Sci Rep
Главные авторы: Nuzzo, Tommaso, Punzo, Daniela, Devoto, Paola, Rosini, Elena, Paciotti, Silvia, Sacchi, Silvia, Li, Qin, Thiolat, Marie-Laure, Véga, Celine, Carella, Massimo, Carta, Manolo, Gardoni, Fabrizio, Calabresi, Paolo, Pollegioni, Loredano, Bezard, Erwan, Parnetti, Lucilla, Errico, Francesco, Usiello, Alessandro
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2019
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6586824/
https://ncbi.nlm.nih.gov/pubmed/31222058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-45419-1
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