An HER2 DNA vaccine with evolution-selected amino acid substitutions reveals a fundamental principle for cancer vaccine formulation in HER2 transgenic mice

Enhancement of endogenous immunity to tumor-associated self-antigens and neoantigens is the goal of preventive vaccination. Toward this goal, we compared the efficacy of the following HER2 DNA vaccine constructs: vaccines encoding wild-type HER2, hybrid HER2 vaccines consisting of human HER2 and rat...

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Veröffentlicht in:Cancer Immunol Immunother
Hauptverfasser: Jones, Richard F., Reyes, Joyce D., Gibson, Heather M., Jacob, Jennifer B., Vaishampayan, Ulka, Ratner, Stuart, Chen, Kang, Wei, Wei-Zen
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer Berlin Heidelberg 2019
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6586491/
https://ncbi.nlm.nih.gov/pubmed/31177328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-019-02333-9
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