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Structural determinants and genetic modifications enhance BMP2 stability and extracellular secretion

The short half‐life and use of recombinant bone morphogenetic protein (BMP)2 in large doses poses major limitations in the clinic. Events regulating posttranslational processing and degradation of BMP2 in situ, linked to its secretion, have not been understood. Toward identifying mechanisms regulati...

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Podrobná bibliografie
Vydáno v:FASEB Bioadv
Hlavní autoři: Khattar, Vinayak, Lee, Joo Hyoung, Wang, Hong, Bastola, Soniya, Ponnazhagan, Selvarangan
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6586023/
https://ncbi.nlm.nih.gov/pubmed/31225515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fba.2018-00023
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