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Structural determinants and genetic modifications enhance BMP2 stability and extracellular secretion
The short half‐life and use of recombinant bone morphogenetic protein (BMP)2 in large doses poses major limitations in the clinic. Events regulating posttranslational processing and degradation of BMP2 in situ, linked to its secretion, have not been understood. Toward identifying mechanisms regulati...
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| Veröffentlicht in: | FASEB Bioadv |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
John Wiley and Sons Inc.
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6586023/ https://ncbi.nlm.nih.gov/pubmed/31225515 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fba.2018-00023 |
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