Pyruvate carboxylase mediated anaplerosis promotes antioxidant capacity by sustaining TCA cycle and redox metabolism in liver

The hepatic TCA cycle supports oxidative and biosynthetic metabolism. This dual responsibility requires anaplerotic pathways, such as pyruvate carboxylase (PC), to generate TCA cycle intermediates necessary for biosynthesis without disrupting oxidative metabolism. Liver-specific PC knockout (LPCKO)...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Cell Metab
Autores principales: Cappel, David A., Deja, Stanisław, Duarte, João A.G., Kucejova, Blanka, Iñigo, Melissa, Fletcher, Justin A., Fu, Xiaorong, Berglund, Eric D., Liu, Tiemin, Elmquist, Joel K., Hammer, Suntrea, Mishra, Prashant, Browning, Jeffrey D., Burgess, Shawn C.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6585968/
https://ncbi.nlm.nih.gov/pubmed/31006591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2019.03.014
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares