Pyruvate carboxylase mediated anaplerosis promotes antioxidant capacity by sustaining TCA cycle and redox metabolism in liver

The hepatic TCA cycle supports oxidative and biosynthetic metabolism. This dual responsibility requires anaplerotic pathways, such as pyruvate carboxylase (PC), to generate TCA cycle intermediates necessary for biosynthesis without disrupting oxidative metabolism. Liver-specific PC knockout (LPCKO)...

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Bibliografiset tiedot
Julkaisussa:Cell Metab
Päätekijät: Cappel, David A., Deja, Stanisław, Duarte, João A.G., Kucejova, Blanka, Iñigo, Melissa, Fletcher, Justin A., Fu, Xiaorong, Berglund, Eric D., Liu, Tiemin, Elmquist, Joel K., Hammer, Suntrea, Mishra, Prashant, Browning, Jeffrey D., Burgess, Shawn C.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2019
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6585968/
https://ncbi.nlm.nih.gov/pubmed/31006591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2019.03.014
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