Pyruvate carboxylase mediated anaplerosis promotes antioxidant capacity by sustaining TCA cycle and redox metabolism in liver

The hepatic TCA cycle supports oxidative and biosynthetic metabolism. This dual responsibility requires anaplerotic pathways, such as pyruvate carboxylase (PC), to generate TCA cycle intermediates necessary for biosynthesis without disrupting oxidative metabolism. Liver-specific PC knockout (LPCKO)...

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Udgivet i:Cell Metab
Main Authors: Cappel, David A., Deja, Stanisław, Duarte, João A.G., Kucejova, Blanka, Iñigo, Melissa, Fletcher, Justin A., Fu, Xiaorong, Berglund, Eric D., Liu, Tiemin, Elmquist, Joel K., Hammer, Suntrea, Mishra, Prashant, Browning, Jeffrey D., Burgess, Shawn C.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6585968/
https://ncbi.nlm.nih.gov/pubmed/31006591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2019.03.014
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