Pyruvate carboxylase mediated anaplerosis promotes antioxidant capacity by sustaining TCA cycle and redox metabolism in liver

The hepatic TCA cycle supports oxidative and biosynthetic metabolism. This dual responsibility requires anaplerotic pathways, such as pyruvate carboxylase (PC), to generate TCA cycle intermediates necessary for biosynthesis without disrupting oxidative metabolism. Liver-specific PC knockout (LPCKO)...

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Pubblicato in:Cell Metab
Autori principali: Cappel, David A., Deja, Stanisław, Duarte, João A.G., Kucejova, Blanka, Iñigo, Melissa, Fletcher, Justin A., Fu, Xiaorong, Berglund, Eric D., Liu, Tiemin, Elmquist, Joel K., Hammer, Suntrea, Mishra, Prashant, Browning, Jeffrey D., Burgess, Shawn C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6585968/
https://ncbi.nlm.nih.gov/pubmed/31006591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2019.03.014
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