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Population Pharmacokinetics and Exposure‐Response Relationship of Intravenous and Subcutaneous Abatacept in Patients With Rheumatoid Arthritis

Abatacept population pharmacokinetics (PK) and exposure‐response (E‐R) models for selective efficacy end points were developed using phase 2 and 3 study data in patients with rheumatoid arthritis treated with abatacept (intravenous [IV] or subcutaneous [SC]), followed by simulations. Two efficacy en...

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Bibliografske podrobnosti
izdano v:J Clin Pharmacol
Main Authors: Li, Xiaohui, Roy, Amit, Murthy, Bindu
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6585965/
https://ncbi.nlm.nih.gov/pubmed/30229926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.1308
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