Activated PPARγ Abrogates Misprocessing of Amyloid Precursor Protein, Tau Missorting and Synaptotoxicity

Type 2 diabetes increases the risk for dementia, including Alzheimer’s disease (AD). Pioglitazone (Pio), a pharmacological agonist of the peroxisome proliferator-activated receptor γ (PPARγ), improves insulin sensitivity and has been suggested to have potential in the management of AD symptoms, albe...

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Détails bibliographiques
Publié dans:Front Cell Neurosci
Auteurs principaux: Moosecker, Susanne, Gomes, Patrícia, Dioli, Chrysoula, Yu, Shuang, Sotiropoulos, Ioannis, Almeida, Osborne F. X.
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2019
Sujets:
Neuroscience
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6584807/
https://ncbi.nlm.nih.gov/pubmed/31263400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2019.00239
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