Cardiac‐specific overexpression of metallothionein attenuates L‐NAME‐induced myocardial contractile anomalies and apoptosis

Hypertension contributes to the high cardiac morbidity and mortality. Although oxidative stress plays an essential role in hypertensive heart diseases, the mechanism remains elusive. Transgenic mice with cardiac overexpression of metallothionein, a heavy metal‐binding scavenger, were challenged with...

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Veröffentlicht in:J Cell Mol Med
Hauptverfasser: Yang, Lifang, Ma, Jipeng, Tan, Ying, Zheng, Qijun, Dong, Maolong, Guo, Wei, Xiong, Lize, Yang, Jian, Ren, Jun
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2019
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6584723/
https://ncbi.nlm.nih.gov/pubmed/31104354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.14375
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