Cardiac‐specific overexpression of metallothionein attenuates L‐NAME‐induced myocardial contractile anomalies and apoptosis

Hypertension contributes to the high cardiac morbidity and mortality. Although oxidative stress plays an essential role in hypertensive heart diseases, the mechanism remains elusive. Transgenic mice with cardiac overexpression of metallothionein, a heavy metal‐binding scavenger, were challenged with...

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Detalhes bibliográficos
Publicado no:J Cell Mol Med
Main Authors: Yang, Lifang, Ma, Jipeng, Tan, Ying, Zheng, Qijun, Dong, Maolong, Guo, Wei, Xiong, Lize, Yang, Jian, Ren, Jun
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6584723/
https://ncbi.nlm.nih.gov/pubmed/31104354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.14375
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