Entry from the Lipid Bilayer: A Possible Pathway for Inhibition of a Peptide G Protein-Coupled Receptor by a Lipophilic Small Molecule

The pathways that G protein-coupled receptor (GPCR) ligands follow as they bind to or dissociate from their receptors are largely unknown. Protease-activated receptor-1 (PAR1) is a GPCR activated by intramolecular binding of a tethered agonist peptide that is exposed by thrombin cleavage. By contras...

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Veröffentlicht in:Biochemistry
Hauptverfasser: Bokoch, Michael P., Jo, Hyunil, Valcourt, James R., Srinivasan, Yoga, Pan, Albert C., Capponi, Sara, Grabe, Michael, Dror, Ron O., Shaw, David E., DeGrado, William F., Coughlin, Shaun R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6584023/
https://ncbi.nlm.nih.gov/pubmed/30102523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b00577
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