Effect of Low-Dose Intracoronary Alteplase During Primary Percutaneous Coronary Intervention on Microvascular Obstruction in Patients With Acute Myocardial Infarction: A Randomized Clinical Trial

IMPORTANCE: Microvascular obstruction commonly affects patients with acute ST-segment elevation myocardial infarction (STEMI) and is associated with adverse outcomes. OBJECTIVE: To determine whether a therapeutic strategy involving low-dose intracoronary fibrinolytic therapy with alteplase infused e...

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Bibliographic Details
Published in:JAMA
Main Authors: McCartney, Peter J., Eteiba, Hany, Maznyczka, Annette M., McEntegart, Margaret, Greenwood, John P., Muir, Douglas F., Chowdhary, Saqib, Gershlick, Anthony H., Appleby, Clare, Cotton, James M., Wragg, Andrew, Curzen, Nick, Oldroyd, Keith G., Lindsay, Mitchell, Rocchiccioli, J. Paul, Shaukat, Aadil, Good, Richard, Watkins, Stuart, Robertson, Keith, Malkin, Christopher, Martin, Lynn, Gillespie, Lynsey, Ford, Thomas J., Petrie, Mark C., Macfarlane, Peter W., Tait, R. Campbell, Welsh, Paul, Sattar, Naveed, Weir, Robin A., Fox, Keith A., Ford, Ian, McConnachie, Alex, Berry, Colin
Format: Artigo
Language:Inglês
Published: American Medical Association 2019
Subjects:
Original Investigation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6583564/
https://ncbi.nlm.nih.gov/pubmed/30620371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jama.2018.19802
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