KU-596 Decreases Mitochondrial Superoxide and Improves Bioenergetics Following Downregulation of Manganese Superoxide Dismutase in Diabetic Sensory Neurons

Neuronal mitochondrial dysfunction and oxidative stress are key pathophysiologic mechanisms of diabetic peripheral neuropathy (DPN). KU-596 is a small molecule modulator of heat shock protein 90 (Hsp90) that can reverse clinically relevant measures of DPN in diabetic animal models. Mechanistically,...

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Bibliografiska uppgifter
I publikationen:Exp Neurol
Huvudupphovsmän: You, Zhenyuan, Zhang, Zheng, Blagg, Brian S. J., Dobrowsky, Rick T.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2018
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6582953/
https://ncbi.nlm.nih.gov/pubmed/30557564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2018.12.006
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