Rosmarinic acid suppresses Alzheimer’s disease development by reducing amyloid β aggregation by increasing monoamine secretion

A new mechanism is revealed by which a polyphenol, rosmarinic acid (RA), suppresses amyloid β (Aβ) accumulation in mice. Here we examined the brains of mice (Alzheimer’s disease model) using DNA microarray analysis and revealed that the dopamine (DA)-signaling pathway was enhanced in the group fed R...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Hase, Tomoki, Shishido, Syun, Yamamoto, So, Yamashita, Rei, Nukima, Haruka, Taira, Shu, Toyoda, Tsudoi, Abe, Keiko, Hamaguchi, Tsuyoshi, Ono, Kenjiro, Noguchi-Shinohara, Moeko, Yamada, Masahito, Kobayashi, Shoko
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6581955/
https://ncbi.nlm.nih.gov/pubmed/31213631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-45168-1
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