Low Polymerase Activity Attributed to PA Drives the Acquisition of the PB2 E627K Mutation of H7N9 Avian Influenza Virus in Mammals

Avian influenza viruses (AIVs) must acquire mammalian-adaptive mutations before they can efficiently replicate in and transmit among humans. The PB2 E627K mutation is known to play a prominent role in the mammalian adaptation of AIVs. The H7N9 AIVs that emerged in 2013 in China easily acquired the P...

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Publicado en:mBio
Main Authors: Liang, Libin, Jiang, Li, Li, Junping, Zhao, Qingqing, Wang, Jinguang, He, Xijun, Huang, Shanyu, Wang, Qian, Zhao, Yuhui, Wang, Guangwen, Sun, Nan, Deng, Guohua, Shi, Jianzhong, Tian, Guobin, Zeng, Xianying, Jiang, Yongping, Liu, Liling, Liu, Jinxiong, Chen, Pucheng, Bu, Zhigao, Kawaoka, Yoshihiro, Chen, Hualan, Li, Chengjun
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2019
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6581862/
https://ncbi.nlm.nih.gov/pubmed/31213560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01162-19
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