Characterization of in vivo tumorigenicity tests using severe immunodeficient NOD/Shi-scid IL2Rγ(null) mice for detection of tumorigenic cellular impurities in human cell-processed therapeutic products

The contamination of human cell-processed therapeutic products (hCTPs) with tumorigenic cells is one of the major concerns in the manufacturing and quality control of hCTPs. However, no quantitative method for detecting the tumorigenic cellular impurities is currently standardized. NOD/Shi-scid IL2R...

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Publicat a:Regen Ther
Autors principals: Kusakawa, Shinji, Machida, Kazuhiko, Yasuda, Satoshi, Takada, Nozomi, Kuroda, Takuya, Sawada, Rumi, Okura, Hanayuki, Tsutsumi, Hideki, Kawamata, Shin, Sato, Yoji
Format: Artigo
Idioma:Inglês
Publicat: Japanese Society for Regenerative Medicine 2015
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6581766/
https://ncbi.nlm.nih.gov/pubmed/31245439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.reth.2014.12.001
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