Characterization of in vivo tumorigenicity tests using severe immunodeficient NOD/Shi-scid IL2Rγ(null) mice for detection of tumorigenic cellular impurities in human cell-processed therapeutic products

The contamination of human cell-processed therapeutic products (hCTPs) with tumorigenic cells is one of the major concerns in the manufacturing and quality control of hCTPs. However, no quantitative method for detecting the tumorigenic cellular impurities is currently standardized. NOD/Shi-scid IL2R...

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Enregistré dans:
Détails bibliographiques
Publié dans:Regen Ther
Auteurs principaux: Kusakawa, Shinji, Machida, Kazuhiko, Yasuda, Satoshi, Takada, Nozomi, Kuroda, Takuya, Sawada, Rumi, Okura, Hanayuki, Tsutsumi, Hideki, Kawamata, Shin, Sato, Yoji
Format: Artigo
Langue:Inglês
Publié: Japanese Society for Regenerative Medicine 2015
Sujets:
Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6581766/
https://ncbi.nlm.nih.gov/pubmed/31245439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.reth.2014.12.001
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