Cryptochromes-mediated Inhibition of the CRL4(Cop1)-Complex Assembly Defines an Evolutionary Conserved Signaling Mechanism

In plants, cryptochromes are photoreceptors that negatively regulate the ubiquitin ligase CRL4(Cop1). In mammals, cryptochromes are core components of the circadian clock and repressors of the glucocorticoid receptor (GR). Moreover, mammalian cryptochromes lost their ability to interact with Cop1, s...

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Pubblicato in:Curr Biol
Autori principali: Rizzini, Luca, Levine, Daniel C., Perelis, Mark, Bass, Joseph, Peek, Clara B., Pagano, Michele
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6581574/
https://ncbi.nlm.nih.gov/pubmed/31155351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2019.04.073
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