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Cryptochromes-mediated Inhibition of the CRL4(Cop1)-Complex Assembly Defines an Evolutionary Conserved Signaling Mechanism
In plants, cryptochromes are photoreceptors that negatively regulate the ubiquitin ligase CRL4(Cop1). In mammals, cryptochromes are core components of the circadian clock and repressors of the glucocorticoid receptor (GR). Moreover, mammalian cryptochromes lost their ability to interact with Cop1, s...
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| Publicado no: | Curr Biol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6581574/ https://ncbi.nlm.nih.gov/pubmed/31155351 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2019.04.073 |
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