An evolutionary hotspot defines functional differences between CRYPTOCHROMES

Mammalian circadian clocks are driven by a transcription/translation feedback loop composed of positive regulators (CLOCK/BMAL1) and repressors (CRYPTOCHROME 1/2 (CRY1/2) and PER1/2). To understand the structural principles of regulation, we used evolutionary sequence analysis to identify co-evolvin...

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Publicado en:Nat Commun
Main Authors: Rosensweig, Clark, Reynolds, Kimberly A., Gao, Peng, Laothamatas, Isara, Shan, Yongli, Ranganathan, Rama, Takahashi, Joseph S., Green, Carla B.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5859286/
https://ncbi.nlm.nih.gov/pubmed/29556064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03503-6
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