Clinical spectrum and pleiotropic nature of CDH1 germline mutations

CDH1 encodes E-cadherin, a key protein in adherens junctions. Given that E-cadherin is involved in major cellular processes such as embryogenesis and maintenance of tissue architecture, it is no surprise that deleterious effects arise from its loss of function. E-cadherin is recognised as a tumour s...

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Detalles Bibliográficos
Publicado en:J Med Genet
Autores principales: Figueiredo, Joana, Melo, Soraia, Carneiro, Patrícia, Moreira, Ana Margarida, Fernandes, Maria Sofia, Ribeiro, Ana Sofia, Guilford, Parry, Paredes, Joana, Seruca, Raquel
Formato: Artigo
Lenguaje:Inglês
Publicado: BMJ Publishing Group 2019
Materias:
Cancer Genetics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6581119/
https://ncbi.nlm.nih.gov/pubmed/30661051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jmedgenet-2018-105807
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