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Predicting the Functional Impact of CDH1 Missense Mutations in Hereditary Diffuse Gastric Cancer
The role of E-cadherin in Hereditary Diffuse Gastric Cancer (HDGC) is unequivocal. Germline alterations in its encoding gene (CDH1) are causative of HDGC and occur in about 40% of patients. Importantly, while in most cases CDH1 alterations result in the complete loss of E-cadherin associated with a...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
MDPI AG
2017-12-01
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| Col·lecció: | International Journal of Molecular Sciences |
| Matèries: | |
| Accés en línia: | https://www.mdpi.com/1422-0067/18/12/2687 |
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