Predicting the Functional Impact of CDH1 Missense Mutations in Hereditary Diffuse Gastric Cancer

The role of E-cadherin in Hereditary Diffuse Gastric Cancer (HDGC) is unequivocal. Germline alterations in its encoding gene (CDH1) are causative of HDGC and occur in about 40% of patients. Importantly, while in most cases CDH1 alterations result in the complete loss of E-cadherin associated with a...

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Bibliographische Detailangaben
Veröffentlicht in:Int J Mol Sci
Hauptverfasser: Melo, Soraia, Figueiredo, Joana, Fernandes, Maria Sofia, Gonçalves, Margarida, Morais-de-Sá, Eurico, Sanches, João Miguel, Seruca, Raquel
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2017
Schlagworte:
Review
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5751289/
https://ncbi.nlm.nih.gov/pubmed/29231860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms18122687
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