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Predicting the Functional Impact of CDH1 Missense Mutations in Hereditary Diffuse Gastric Cancer
The role of E-cadherin in Hereditary Diffuse Gastric Cancer (HDGC) is unequivocal. Germline alterations in its encoding gene (CDH1) are causative of HDGC and occur in about 40% of patients. Importantly, while in most cases CDH1 alterations result in the complete loss of E-cadherin associated with a...
Gardado en:
| Publicado en: | Int J Mol Sci |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
MDPI
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5751289/ https://ncbi.nlm.nih.gov/pubmed/29231860 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms18122687 |
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