Cellular DNAJA3, a Novel VP1-Interacting Protein, Inhibits Foot-and-Mouth Disease Virus Replication by Inducing Lysosomal Degradation of VP1 and Attenuating Its Antagonistic Role in the Beta Interferon Signaling Pathway

DnaJ heat shock protein family (Hsp40) member A3 (DNAJA3) plays an important role in viral infections. However, the role of DNAJA3 in replication of foot-and-mouth-disease virus (FMDV) remains unknown. In this study, DNAJA3, a novel binding partner of VP1, was identified using yeast two-hybrid scree...

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Publicado en:J Virol
Autores principales: Zhang, Wei, Yang, Fan, Zhu, Zixiang, Yang, Yang, Wang, Zhifang, Cao, Weijun, Dang, Wen, Li, Linlin, Mao, Ruoqing, Liu, Yongjie, Tian, Hong, Zhang, Keshan, Liu, Xiangtao, Ma, Junwu, Zheng, Haixue
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2019
Materias:
Virus-Cell Interactions
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6580959/
https://ncbi.nlm.nih.gov/pubmed/30996089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00588-19
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