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Cellular DNAJA3, a Novel VP1-Interacting Protein, Inhibits Foot-and-Mouth Disease Virus Replication by Inducing Lysosomal Degradation of VP1 and Attenuating Its Antagonistic Role in the Beta Interferon Signaling Pathway

DnaJ heat shock protein family (Hsp40) member A3 (DNAJA3) plays an important role in viral infections. However, the role of DNAJA3 in replication of foot-and-mouth-disease virus (FMDV) remains unknown. In this study, DNAJA3, a novel binding partner of VP1, was identified using yeast two-hybrid scree...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:J Virol
المؤلفون الرئيسيون: Zhang, Wei, Yang, Fan, Zhu, Zixiang, Yang, Yang, Wang, Zhifang, Cao, Weijun, Dang, Wen, Li, Linlin, Mao, Ruoqing, Liu, Yongjie, Tian, Hong, Zhang, Keshan, Liu, Xiangtao, Ma, Junwu, Zheng, Haixue
التنسيق: Artigo
اللغة:Inglês
منشور في: American Society for Microbiology 2019
الموضوعات:
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC6580959/
https://ncbi.nlm.nih.gov/pubmed/30996089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00588-19
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