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Deep Mutational Scan of the Highly Conserved Influenza A Virus M1 Matrix Protein Reveals Substantial Intrinsic Mutational Tolerance

Influenza A virus matrix protein M1 is involved in multiple stages of the viral infectious cycle. Despite its functional importance, our present understanding of this essential viral protein is limited. The roles of a small subset of specific amino acids have been reported, but a more comprehensive...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Hom, Nancy, Gentles, Lauren, Bloom, Jesse D., Lee, Kelly K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6580950/
https://ncbi.nlm.nih.gov/pubmed/31019050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00161-19
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