Discovery of a Lead Triphenylethanamine Cholesterol Ester Transfer Protein (CETP) Inhibitor

[Image: see text] Lead optimization of the diphenylpyridylethanamine (DPPE) and triphenylethanamine (TPE) series of CETP inhibitors to improve their pharmaceutical profile is described. Polar groups at the N-terminus position in the DPPE series resulted in further improvement in potency and pharmace...

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Опубликовано в: :ACS Med Chem Lett
Главные авторы: Finlay, Heather J., Jiang, Ji, Rampulla, Richard, Salvati, Mark E., Qiao, Jennifer X., Wang, Tammy C., Lawrence, R. Michael, Harikrishnan, Lalgudi S., Kamau, Muthoni G., Taylor, David S., Chen, Alice Ye A., Yin, Xiaohong, Huang, Christine S., Chang, Ming, Chen, Xue-Qing, Sleph, Paul G., Xu, Carrie, Li, Julia, Levesque, Paul, Adam, Leonard P., Wexler, Ruth R.
Формат: Artigo
Язык:Inglês
Опубликовано: American Chemical Society 2019
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6580557/
https://ncbi.nlm.nih.gov/pubmed/31223447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00086
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