Discovery of a Lead Triphenylethanamine Cholesterol Ester Transfer Protein (CETP) Inhibitor

[Image: see text] Lead optimization of the diphenylpyridylethanamine (DPPE) and triphenylethanamine (TPE) series of CETP inhibitors to improve their pharmaceutical profile is described. Polar groups at the N-terminus position in the DPPE series resulted in further improvement in potency and pharmace...

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Udgivet i:ACS Med Chem Lett
Main Authors: Finlay, Heather J., Jiang, Ji, Rampulla, Richard, Salvati, Mark E., Qiao, Jennifer X., Wang, Tammy C., Lawrence, R. Michael, Harikrishnan, Lalgudi S., Kamau, Muthoni G., Taylor, David S., Chen, Alice Ye A., Yin, Xiaohong, Huang, Christine S., Chang, Ming, Chen, Xue-Qing, Sleph, Paul G., Xu, Carrie, Li, Julia, Levesque, Paul, Adam, Leonard P., Wexler, Ruth R.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2019
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6580557/
https://ncbi.nlm.nih.gov/pubmed/31223447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00086
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