Discovery of a Lead Triphenylethanamine Cholesterol Ester Transfer Protein (CETP) Inhibitor

[Image: see text] Lead optimization of the diphenylpyridylethanamine (DPPE) and triphenylethanamine (TPE) series of CETP inhibitors to improve their pharmaceutical profile is described. Polar groups at the N-terminus position in the DPPE series resulted in further improvement in potency and pharmace...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:ACS Med Chem Lett
Egile Nagusiak: Finlay, Heather J., Jiang, Ji, Rampulla, Richard, Salvati, Mark E., Qiao, Jennifer X., Wang, Tammy C., Lawrence, R. Michael, Harikrishnan, Lalgudi S., Kamau, Muthoni G., Taylor, David S., Chen, Alice Ye A., Yin, Xiaohong, Huang, Christine S., Chang, Ming, Chen, Xue-Qing, Sleph, Paul G., Xu, Carrie, Li, Julia, Levesque, Paul, Adam, Leonard P., Wexler, Ruth R.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Chemical Society 2019
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6580557/
https://ncbi.nlm.nih.gov/pubmed/31223447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00086
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak