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Recurrent glucose deprivation leads to the preferential use of lactate by neurons in the ventromedial hypothalamus

Increased GABAergic output in the ventromedial hypothalamus (VMH) contributes to counterregulatory failure in recurrently hypoglycemic (RH) rats, and lactate, an alternate fuel source in the brain, contributes to this phenomenon. The current study assessed whether recurring bouts of glucose deprivat...

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Publicado en:Am J Physiol Endocrinol Metab
Autores principales: Shah, Maitreyee, Addison, Augustina, Wang, Peili, Zhu, Wanling, Chan, Owen
Formato: Artigo
Lenguaje:Inglês
Publicado: American Physiological Society 2019
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6580165/
https://ncbi.nlm.nih.gov/pubmed/30888861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00468.2018
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