The role of properdin in complement-mediated renal diseases: a new player in complement-inhibiting therapy?

Properdin is known as the only positive regulator of the complement system. Properdin promotes the activity of this defense system by stabilizing its key enzymatic complexes: the complement alternative pathway (AP) convertases. Besides, some studies have indicated a role for properdin as an initiato...

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Udgivet i:Pediatr Nephrol
Main Authors: Michels, Marloes A. H. M., Volokhina, Elena B., van de Kar, Nicole C. A. J., van den Heuvel, Lambertus P. W. J.
Format: Artigo
Sprog:Inglês
Udgivet: Springer Berlin Heidelberg 2018
Fag:
Educational Review
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6579773/
https://ncbi.nlm.nih.gov/pubmed/30141176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00467-018-4042-z
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