Preventing an Antigenically Disruptive Mutation in Egg-Based H3N2 Seasonal Influenza Vaccines by Mutational Incompatibility

Egg-based seasonal influenza vaccines are the major preventive countermeasure against influenza virus. However, their effectiveness can be compromised when antigenic changes arise from egg-adaptive mutations on influenza hemagglutinin (HA). The L194P mutation is commonly observed in egg-based H3N2 v...

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發表在:Cell Host Microbe
Main Authors: Wu, Nicholas C., Lv, Huibin, Thompson, Andrew J., Wu, Douglas C., Ng, Wilson W.S., Kadam, Rameshwar U., Lin, Chih-Wei, Nycholat, Corwin M., McBride, Ryan, Liang, Weiwen, Paulson, James C., Mok, Chris K.P., Wilson, Ian A.
格式: Artigo
語言:Inglês
出版: Cell Press 2019
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6579542/
https://ncbi.nlm.nih.gov/pubmed/31151913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2019.04.013
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