Preventing an Antigenically Disruptive Mutation in Egg-Based H3N2 Seasonal Influenza Vaccines by Mutational Incompatibility

Egg-based seasonal influenza vaccines are the major preventive countermeasure against influenza virus. However, their effectiveness can be compromised when antigenic changes arise from egg-adaptive mutations on influenza hemagglutinin (HA). The L194P mutation is commonly observed in egg-based H3N2 v...

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Publicado no:Cell Host Microbe
Main Authors: Wu, Nicholas C., Lv, Huibin, Thompson, Andrew J., Wu, Douglas C., Ng, Wilson W.S., Kadam, Rameshwar U., Lin, Chih-Wei, Nycholat, Corwin M., McBride, Ryan, Liang, Weiwen, Paulson, James C., Mok, Chris K.P., Wilson, Ian A.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6579542/
https://ncbi.nlm.nih.gov/pubmed/31151913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2019.04.013
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