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Influenza Virus Neuraminidases with Reduced Enzymatic Activity That Avidly Bind Sialic Acid Receptors

Influenza virus neuraminidase (NA) cleaves off sialic acid from cellular receptors of hemagglutinin (HA) to enable progeny escape from infected cells. However, NA variants (D151G) of recent human H3N2 viruses have also been reported to bind receptors on red blood cells, but the nature of these recep...

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Detalhes bibliográficos
Main Authors: Zhu, Xueyong, McBride, Ryan, Nycholat, Corwin M., Yu, Wenli, Paulson, James C., Wilson, Ian A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3503043/
https://ncbi.nlm.nih.gov/pubmed/23015718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01426-12
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