Partial ligand-receptor engagement yields functional bias at the human complement receptor, C5aR1

The human complement component, C5a, binds two different seven-transmembrane receptors termed C5aR1 and C5aR2. C5aR1 is a prototypical G-protein–coupled receptor that couples to the Gα(i) subfamily of heterotrimeric G-proteins and β-arrestins (βarrs) following C5a stimulation. Peptide fragments deri...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Pandey, Shubhi, Li, Xaria X., Srivastava, Ashish, Baidya, Mithu, Kumari, Punita, Dwivedi, Hemlata, Chaturvedi, Madhu, Ghosh, Eshan, Woodruff, Trent M., Shukla, Arun K.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2019
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6579481/
https://ncbi.nlm.nih.gov/pubmed/31036565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.007485
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