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Partial ligand-receptor engagement yields functional bias at the human complement receptor, C5aR1
The human complement component, C5a, binds two different seven-transmembrane receptors termed C5aR1 and C5aR2. C5aR1 is a prototypical G-protein–coupled receptor that couples to the Gα(i) subfamily of heterotrimeric G-proteins and β-arrestins (βarrs) following C5a stimulation. Peptide fragments deri...
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| Pubblicato in: | J Biol Chem |
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| Autori principali: | , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6579481/ https://ncbi.nlm.nih.gov/pubmed/31036565 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.007485 |
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