Targeted genomic deletions identify diverse enhancer functions and generate a kidney-specific, endocrine-deficient Cyp27b1 pseudo-null mouse

Vitamin D(3) is terminally bioactivated in the kidney to 1α,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) via cytochrome P450 family 27 subfamily B member 1 (CYP27B1), whose gene is regulated by parathyroid hormone (PTH), fibroblast growth factor 23 (FGF23), and 1,25(OH)(2)D(3). Our recent genomic stud...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Meyer, Mark B., Benkusky, Nancy A., Kaufmann, Martin, Lee, Seong Min, Redfield, Robert R., Jones, Glenville, Pike, J. Wesley
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Gene Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6579472/
https://ncbi.nlm.nih.gov/pubmed/31053643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.008760
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