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A High-Calcium and Phosphate Rescue Diet and VDR-Expressing Transgenes Normalize Serum Vitamin D Metabolite Profiles and Renal Cyp27b1 and Cyp24a1 Expression in VDR Null Mice
Vitamin D receptor (VDR)-mediated 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3))-dependent gene expression is compromised in the VDR null mouse. The biological consequences include: hypocalcemia, hypophosphatemia, elevated parathyroid hormone (PTH) and 1,25(OH)(2)D(3), and consequential skeletal abnor...
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| 發表在: | Endocrinology |
|---|---|
| Main Authors: | , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Endocrine Society
2015
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4655220/ https://ncbi.nlm.nih.gov/pubmed/26441239 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2015-1664 |
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