A High-Calcium and Phosphate Rescue Diet and VDR-Expressing Transgenes Normalize Serum Vitamin D Metabolite Profiles and Renal Cyp27b1 and Cyp24a1 Expression in VDR Null Mice

Vitamin D receptor (VDR)-mediated 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3))-dependent gene expression is compromised in the VDR null mouse. The biological consequences include: hypocalcemia, hypophosphatemia, elevated parathyroid hormone (PTH) and 1,25(OH)(2)D(3), and consequential skeletal abnor...

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Publicado en:Endocrinology
Autores principales: Kaufmann, Martin, Lee, Seong Min, Pike, J. Wesley, Jones, Glenville
Formato: Artigo
Lenguaje:Inglês
Publicado: Endocrine Society 2015
Materias:
Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4655220/
https://ncbi.nlm.nih.gov/pubmed/26441239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2015-1664
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