Loss of the p53 transactivation domain results in high amyloid aggregation of the Δ40p53 isoform in endometrial carcinoma cells

Dysfunctional p53 formation and activity can result from aberrant expression and subcellular localization of distinct p53 isoforms or aggregates. Endometrial carcinoma (EC) is a cancer type in which p53 status is correlated with prognosis, and TP53 mutations are a frequent genetic modification. Here...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Melo dos Santos, Nataly, de Oliveira, Guilherme A. P., Ramos Rocha, Murilo, Pedrote, Murilo M., Diniz da Silva Ferretti, Giulia, Pereira Rangel, Luciana, Morgado-Diaz, José A., Silva, Jerson L., Rodrigues Pereira Gimba, Etel
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2019
Schlagworte:
Protein Structure and Folding
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6579457/
https://ncbi.nlm.nih.gov/pubmed/31028175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.007566
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