Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for thiopurine dosing based on TPMT and NUDT15 genotypes: 2018 update

TPMT activity exhibits a monogenic co-dominant inheritance and catabolizes thiopurines. TPMT variant alleles are associated with low enzyme activity and pronounced pharmalogic effecs of thiopurines. Loss-of-function alleles in the NUDT15 gene are common in Asians and Hispanics and reduces the degrad...

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Опубликовано в: :Clin Pharmacol Ther
Главные авторы: Relling, Mary V., Schwab, Matthias, Whirl-Carrillo, Michelle, Suarez-Kurtz, Guilherme, Pui, Ching-Hon, Stein, Charles M., Moyer, Ann M., Evans, William E., Klein, Teri E., Antillon-Klussmann, Federico Guillermo, Caudle, Kelly E., Kato, Motohiro, Yeoh, Allen EJ, Schmiegelow, Kjeld, Yang, Jun J.
Формат: Artigo
Язык:Inglês
Опубликовано: 2019
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6576267/
https://ncbi.nlm.nih.gov/pubmed/30447069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.1304
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