The neurotoxic carboxy-terminal fragment of the Alzheimer amyloid precursor binds specifically to a neuronal cell surface molecule: pH dependence of the neurotoxicity and the binding

One of the hallmarks of Alzheimer's disease neurodegeneration is the accumulation of deposits of amyloid in neuritic plaques and in the cerebral vasculature. Recent studies have implicated carboxy-terminal fragments of the Alzheimer amyloid precursor protein (beta APP) in the processes of amylo...

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Detalles Bibliográficos
Publicado en:J Neurosci
Main Authors: Kozlowski, MR, Spanoyannis, A, Manly, SP, Fidel, SA, Neve, RL
Formato: Artigo
Idioma:Inglês
Publicado: Society for Neuroscience 1992
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6575880/
https://ncbi.nlm.nih.gov/pubmed/1578262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.12-05-01679.1992
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