SCF(FBXO22) targets HDM2 for degradation and modulates breast cancer cell invasion and metastasis

Human homolog of mouse double minute 2 (HDM2) is an oncogene frequently overexpressed in cancers with poor prognosis, but mechanisms of controlling its abundance remain elusive. In an unbiased biochemical search, we discovered Skp1-Cullin 1-FBXO22-ROC1 (SCF(FBXO22)) as the most dominating HDM2 E3 ub...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Bai, Jin, Wu, Kenneth, Cao, Meng-Han, Yang, Yingying, Pan, Yu, Liu, Hui, He, Yizhou, Itahana, Yoko, Huang, Lan, Zheng, Jun-Nian, Pan, Zhen-Qiang
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6575577/
https://ncbi.nlm.nih.gov/pubmed/31138683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1820990116
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