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Processing of beta-amyloid precursor protein in microglia and astrocytes favors an internal localization over constitutive secretion

Microglial cells and astrocytes are closely associated with nearly all compact deposits of the amyloid beta-protein found in the senile plaques characteristic of Alzheimer's disease and trisomy 21. The biosynthesis and metabolic fate of the beta-amyloid precursor protein (beta APP) in astrocyte...

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Publicat a:J Neurosci
Autors principals: Haass, C, Hung, AY, Selkoe, DJ
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 1991
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6575298/
https://ncbi.nlm.nih.gov/pubmed/1744690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.11-12-03783.1991
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