Opposite Modulation of Opiate Withdrawal Behaviors on Microinfusion of a Protein Kinase A Inhibitor Versus Activator into the Locus Coeruleus or Periaqueductal Gray

Chronic opiate administration upregulates the cAMP pathway in the locus coeruleus (LC). This adaptation is thought to increase the electrical excitability of LC neurons and contribute to the dramatic increase in LC firing induced by opioid receptor antagonists in opiate-dependent animals. The goal o...

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Udgivet i:J Neurosci
Main Authors: Punch, Laurie J., Self, David W., Nestler, Eric J., Taylor, Jane R.
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 1997
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6573752/
https://ncbi.nlm.nih.gov/pubmed/9334424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.17-21-08520.1997
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