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Mutation Causing Autosomal Dominant Nocturnal Frontal Lobe Epilepsy Alters Ca(2+) Permeability, Conductance, and Gating of Human α4β2 Nicotinic Acetylcholine Receptors

A mutation (S247F) in the channel-lining domain (M2) of the α4 nicotinic acetylcholine receptor (AChR) subunit has previously been linked genetically to autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE). To better understand the functional significance of this mutation, we characterized th...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:J Neurosci
Hauptverfasser: Kuryatov, Alexander, Gerzanich, Volodymyr, Nelson, Mark, Olale, Felix, Lindstrom, Jon
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 1997
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6573611/
https://ncbi.nlm.nih.gov/pubmed/9364050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.17-23-09035.1997
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