Mutation Causing Autosomal Dominant Nocturnal Frontal Lobe Epilepsy Alters Ca(2+) Permeability, Conductance, and Gating of Human α4β2 Nicotinic Acetylcholine Receptors

A mutation (S247F) in the channel-lining domain (M2) of the α4 nicotinic acetylcholine receptor (AChR) subunit has previously been linked genetically to autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE). To better understand the functional significance of this mutation, we characterized th...

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Bibliographic Details
Published in:J Neurosci
Main Authors: Kuryatov, Alexander, Gerzanich, Volodymyr, Nelson, Mark, Olale, Felix, Lindstrom, Jon
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 1997
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6573611/
https://ncbi.nlm.nih.gov/pubmed/9364050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.17-23-09035.1997
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